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#ROCK POCKET MOUSE WORKSHEET ANSWER KEY CODE#

Of the five mutations you identified in the Mc1r gene, how many are the following: 5 substitutions, 0 insertions, 0 deletions 3. Using the amino acid location numbers provided above the first and last column of each table, list the locations of the five amino acids that contain a mutation. Molecular Genetics of Color Mutations in Rock Pocket Mice of 5 WILD-TYPE MC1R GENE (LIGHT-COLORED COAT PHENOTYPE) MUTANT MC1R GENE (DARK-COLORED COAT PHENOTYPE) DNA mRNA Amino Acid

You could assign analysis questions as homework to reduce the amount of class time required for this lesson.

If you do not have access to a color printer to print the charts below, you should compare students’ work to how the charts below appear on your computer screen.

Students use color to classify mutation types in Step 5 of the procedure.

#ROCK POCKET MOUSE WORKSHEET ANSWER KEY CODE#

MATERIALS genetic code chart blue, red, and green colored pencils TEACHING TIPS

Molecular Genetics of Color Mutations in Rock Pocket Mice Published July 2012 Revised October 2013 of 5 Finally, students should understand that a protein’s structure determines its function and the basics of transmembrane protein structure. PRIOR KNOWLEDGE Students should be familiar with the definitions of “gene” and “protein.” They should also be comfortable with basic molecular genetics, including a familiarity with the processes of transcription and translation and a general understanding of how mutations affect these processes. SUGGESTED AUDIENCE This lesson is appropriate for high school biology (all levels including AP and IB) and introductory college biology.

KEY TERMS adaptation, evolution, mutation, natural selection, trait, variation TIME REQUIREMENTS This lesson was designed to be completed within one 50-minute class period additional time for the analysis questions might be required depending on students’ pace. connect DNA changes to gene expression and phenotype and ĬURRICULUM CONNECTIONS Curriculum NGSS (April 2013) Common Core (2010) AP Biology (2012–13) IB Biology (2009).The environment contributes to determining whether a mutation is advantageous, deleterious, or neutral.Both the type of mutation and its location determine whether or not it will have an effect on phenotype.Most mutations have no effect on traits, but some mutations affect the expression of a gene and/ or the gene product.A mutation is a random change to an organism’s DNA sequence.Students form a hypothesis to explain how a change in amino acid sequence affects the functionality of the melanocortin 1 receptor (MC1R) protein and how that change might directly affect the coat color of the rock pocket mouse populations. By comparing DNA sequences, students identify the locations and types of mutations responsible for the coat-color change described in the film.

Students transcribe and translate portions of the wild-type and mutant rock pocket mouse Mc1r gene. MOLECULAR GENETICS OF COLOR MUTATIONS IN ROCK POCKET MICE OVERVIEW This lesson serves as an extension to the short film The Making of the Fittest: Natural Selection and Adaptation (). The Making of the Fittest: Natural Selection and Adaptation